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研究领域(方向)

胸部恶性肿瘤的临床与基础研究。

个人及工作简历

教授,博士生导师,胸外2科主任,医学博士,中国民革会员。

  1984年自西安医科大学毕业后一直在402com永利1站医学院第一附属医院从事临床,教学与科研工作。对常见肿瘤的诊治积累了丰富的经验,擅长乳腺癌、呼吸及消化道的临床诊治,对一些疑难并发症的处理,有丰富的临床经验。2001-2009年期间先后10次赴美在迈阿密大学癌症中心、得克萨斯大学Anderson癌症中心、芝加哥大学癌症中心研修深造,并且多次参加欧美、东南亚、韩国、港澳等地的大型国际学术会议。

  所带领的团队在本专业领域先后主持开展了乳腺癌、肺癌的微创外科治疗,低位直肠癌保肛术、中晚期食管癌术前新辅助化疗临床前瞻性研究、654-2在开胸手术围手术期的应用等。2005年、2006年、2007年连续三年荣获“医院年度手术量前十名奖”。医德医风考评在科室始终名列前茅。所带领团队近年来取得的科技成果先后获得陕西省科学技术一等奖、二等奖、三等奖各一项,陕西省高等学校科学技术二等奖两项、西安市科学技术三等奖一项,获院新医疗新技术三等奖一项。

  现担任国家医学考试中心医师资格考试试题开发专家、中国抗癌协会乳腺癌专业委员会中青年委员、中国抗癌协会胃癌专业委员会委员、中国肺癌防治联盟402com永利6站一附院肺小结节诊治中心主任,陕西省抗癌协会常务理事,陕西省抗癌协会肺癌专业委员会主任委员、陕西抗癌协会乳腺癌专业委员会名誉主任委员、陕西省抗癌协会食管癌专业委员会副主任委员、陕西省医学会营养专业委员会常委、美国抗癌协会会员、国际肺癌协会会员、402com永利1站肝胆胰疾病研究会常务理事、《中国微创外科杂志》特约编委、《肝胆胰外科杂志》特约编委等职务,教育部博士研究生论文评审特聘专家。通讯作者发表论文150余篇,其中SCI 20余篇。主编、参编医学专著5部,卫生部视听教材一部。曾多次主持、参与多项国家级、省级基金的攻关,并多次接受国家自然科学基金委员会委托参与“国家自然科学基金”项目申报的评审工作。现主持国家自然科学基金2项,省自然科学基金1项、主持陕西省、西安市科技攻关项目各1项。

科研项目

1.Hsa-let-7通过ER影响Wnt信号通路而维持雌激素受体阳性乳腺癌干细胞的功能及机制研究  国家自然科学基金   负责人

2.Smac/Survivin对胰腺癌Bx_PC3细胞凋亡的调控作用及其机制研究(30740022)国家自然科学基金   负责人

3.脐血DC细胞与胆囊癌细胞融合瘤苗的免疫调节作用研究(2006C219)
陕西省自然科学基金    负责人

4.血管生长抑制素对实验性胰腺癌生长和转移抑制的研究(2003K10G54)
  陕西省科技攻关    负责人

5.食管癌术前化疗的临床应用及预测化疗敏感性的相关分子标志物研究(SF200329)
 西安市科技攻关    负责人

6.过表达Smac基因治疗肺癌的体内和体外研究(2010k01-133)陕西省科技攻关    负责人

7.MiR-367通过FBXW7调控NSCLC恶性进展的作用及其机制研究  (2017KW-061) 陕西省重点研发计划  国际合作项目  负责人

学术及科研成果、专利、论文

1. MiR-129 blocks estrogen induction of NOTCH signaling activity in breast cancer stem-like cells.
Xiao G, Li X, Li G, Zhang B, Xu C, Qin S, Du N, Wang J, Tang SC, Zhang J, Ren H, Chen K, Sun X.
Oncotarget. 2017 Sep 21;8(61):103261-103273. doi: 10.18632/oncotarget.21143. eCollection 2017 Nov 28.

2. Clinical Application of Detecting 21-Gene Recurrence Score in Predicating Prognosis and Therapy Response of Patients with Breast Cancer from Two Medical Centers.
Xiao G, Meng J, Zhang J, Li G, Du N, Qin S, Wang J, Xu C, Ren H, Tang SC, Sun X.
Cancer Invest. 2017 Nov 26;35(10):639-646. doi: 10.1080/07357907.2017.1405015.

3. Analysis of risk factors for post-operative complications and prognostic predictors of disease recurrence following definitive treatment of patients with esophageal cancer from two medical centers in Northwest China.
Wang J, Zhang B, Meng J, Xiao G, Li X, Li G, Qin S, Du N, Zhang J, Zhang J, Xu C, Tang SC, Liang R, Ren H, Sun X.
Exp Ther Med. 2017 Sep;14(3):2584-2594. doi: 10.3892/etm.2017.4835. Epub 2017 Jul 25.

4. miR-367 stimulates Wnt cascade activation through degrading FBXW7 in NSCLC stem cells.
Xiao G, Zhang B, Meng J, Wang J, Xu C, Tang SC, Li X, Zhang J, Liang R, Ren H, Sun X.
Cell Cycle. 2017;16(24):2374-2385. doi: 10.1080/15384101.2017.1380136. Epub 2017 Nov 14.

5. Augmented expression of polo-like kinase 1 indicates poor clinical outcome for breast patients: a systematic review and meta-analysis.
Zhang Y, Wu Z, Liu D, Wang M, Xiao G, Wang P, Sun X, Ren H, Tang SC, Du N.
Oncotarget. 2017 Apr 20;8(34):57723-57732. doi: 10.18632/oncotarget.17301. eCollection 2017 Aug 22. Review.

6. Nano Let 7b sensitization of eliminating esophageal cancer stem like cells is dependent on blockade of Wnt activation of symmetric division.
Pang Y, Liu J, Li X, Zhang Y, Zhang B, Zhang J, Du N, Xu C, Liang R, Ren H, Tang SC, Sun X.
Int J Oncol. 2017 Oct;51(4):1077-1088. doi: 10.3892/ijo.2017.4104. Epub 2017 Aug 29.

7. Association of baseline vitamin D level with genetic determinants and virologic response in patients with chronic hepatitis B.
Yu R, Tan D, Ning Q, Niu J, Bai X, Chen S, Cheng J, Yu Y, Wang H, Xu M, Shi G, Wan M, Chen X, Tang H, Sheng J, Dou X, Shi J, Ren H, Wang M, Zhang H, Gao Z, Chen C, Ma H, Jia J, Hou J, Xie Q, Sun J.
Hepatol Res. 2017 Aug 23. doi: 10.1111/hepr.12972. [Epub ahead of print]

8. miR-367 promotes tumor growth by inhibiting FBXW7 in NSCLC.
Xiao G, Gao X, Sun X, Yang C, Zhang B, Sun R, Huang G, Li X, Liu J, Du N, Liu D, Liang R, Ren H, Qin S.
Oncol Rep. 2017 Aug;38(2):1190-1198. doi: 10.3892/or.2017.5755. Epub 2017 Jun 27.

9. CSH guidelines for the diagnosis and treatment of drug-induced liver injury.
Yu YC, Mao YM, Chen CW, Chen JJ, Chen J, Cong WM, Ding Y, Duan ZP, Fu QC, Guo XY, Hu P, Hu XQ, Jia JD, Lai RT, Li DL, Liu YX, Lu LG, Ma SW, Ma X, Nan YM, Ren H, Shen T, Wang H, Wang JY, Wang TL, Wang XJ, Wei L, Xie Q, Xie W, Yang CQ, Yang DL, Yu YY, Zeng MD, Zhang L, Zhao XY, Zhuang H; Drug-induced Liver Injury (DILI) Study Group; Chinese Society of Hepatology (CSH); Chinese Medical Association (CMA).
Hepatol Int. 2017 May;11(3):221-241. doi: 10.1007/s12072-017-9793-2. Epub 2017 Apr 12.

10. Sox2 inhibits Wnt-β-catenin signaling and metastatic potency of cisplatin-resistant lung adenocarcinoma cells.
He J, Shi J, Zhang K, Xue J, Li J, Yang J, Chen J, Wei J, Ren H, Liu X.
Mol Med Rep. 2017 Apr;15(4):1693-1701. doi: 10.3892/mmr.2017.6170. Epub 2017 Feb 6.
11. LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC.
Yang C, Wang H, Zhang B, Chen Y, Zhang Y, Sun X, Xiao G, Nan K, Ren H, Qin S.
J Exp Clin Cancer Res. 2016 Sep 30;35(1):158.
12. Identification of novel susceptibility markers for the risk of overall breast cancer as well as subtypes defined by hormone receptor status in the Chinese population.
Deng Z, Yang H, Liu Q, Wang Z, Feng T, Ouyang Y, Jin T, Ren H.
J Hum Genet. 2016 Dec;61(12):1027-1034. doi: 10.1038/jhg.2016.97. Epub 2016 Sep 8.

13. OTUD7B and NIK expression in non-small cell lung cancer: Association with clinicopathological features and prognostic implications.
Zhang B, Wang H, Yang L, Zhang Y, Wang P, Huang G, Zheng J, Ren H, Qin S.
Pathol Res Pract. 2016 Oct;212(10):893-898. doi: 10.1016/j.prp.2016.07.011. Epub 2016 Jul 25.

14. XIAP inhibits mature Smac-induced apoptosis by degrading it through ubiquitination in NSCLC.
Qin S, Yang C, Zhang B, Li X, Sun X, Li G, Zhang J, Xiao G, Gao X, Huang G, Wang P, Ren H.
Int J Oncol. 2016 Oct;49(4):1289-96. doi: 10.3892/ijo.2016.3634. Epub 2016 Jul 27.

15. Fibronectin protects lung cancer cells against docetaxel-induced apoptosis by promoting Src and caspase-8 phosphorylation.
Qin S, Zhang B, Xiao G, Sun X, Li G, Huang G, Gao X, Li X, Wang H, Yang C, Ren H.
Tumour Biol. 2016 Oct;37(10):13509-13520. Epub 2016 Jul 28.

16. Will Sofosbuvir/Ledipasvir (Harvoni) Be Cost-Effective and Affordable for Chinese Patients Infected with Hepatitis C Virus? An Economic Analysis Using Real-World Data.
Chen GF, Wei L, Chen J, Duan ZP, Dou XG, Xie Q, Zhang WH, Lu LG, Fan JG, Cheng J, Wang GQ, Ren H, Wang JP, Yang XX, Jia ZS, Fu QC, Wang XJ, Shang J, Zhang YX, Han Y, Du N, Shao Q, Ji D, Li F, Li B, Liu JL, Niu XX, Wang C, Wu V, Wong A, Wang YD, Hou JL, Jia JD, Zhuang H, Lau G.
PLoS One. 2016 Jun 8;11(6):e0155934. doi: 10.1371/journal.pone.0155934. eCollection 2016.

17. FOXQ1 promotes gastric cancer metastasis through upregulation of Snail.
Zhang J, Liu Y, Zhang J, Cui X, Li G, Wang J, Ren H, Zhang Y.
Oncol Rep. 2016 Jun;35(6):3607-13. doi: 10.3892/or.2016.4736. Epub 2016 Apr 8.

18. The insights of Let-7 miRNAs in oncogenesis and stem cell potency.
Sun X, Liu J, Xu C, Tang SC, Ren H.
J Cell Mol Med. 2016 Sep;20(9):1779-88. doi: 10.1111/jcmm.12861. Epub 2016 Apr 21. Review.

19. CDH1 promoter methylation correlates with decreased gene expression and poor prognosis in patients with breast cancer.
Liu J, Sun X, Qin S, Wang H, DU N, Li Y, Pang Y, Wang C, Xu C, Ren H.
Oncol Lett. 2016 Apr;11(4):2635-2643. Epub 2016 Feb 24.

20. [miR-101 inhibits the proliferation and migration of breast cancer cells via downregulating the expression of DNA methyltransferase 3a].
Liu J, Pang Y, Wang H, Li Y, Sun X, Xu F, Ren H, Liu D.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Mar;32(3):299-303. Chinese.

21. MiR-208a stimulates the cocktail of SOX2 and β-catenin to inhibit the let-7 induction of self-renewal repression of breast cancer stem cells and formed miR208a/let-7 feedback loop via LIN28 and DICER1.
Sun X, Jiang S, Liu J, Wang H, Zhang Y, Tang SC, Wang J, Du N, Xu C, Wang C, Qin S, Zhang J, Liu D, Zhang Y, Li X, Wang J, Dong J, Wang X, Xu S, Tao Z, Xu F, Zhou J, Wang T, Ren H.
Oncotarget. 2015 Oct 20;6(32):32944-54. doi: 10.18632/oncotarget.5079.

22. Hyperthermia induces apoptosis by targeting Survivin in esophageal cancer.
Qin S, Xu C, Li S, Wang X, Sun X, Wang P, Zhang B, Ren H.
Oncol Rep. 2015 Nov;34(5):2656-64. doi: 10.3892/or.2015.4252. Epub 2015 Sep 8.

23. Curcumin inhibits lung cancer invasion and metastasis by attenuating GLUT1/MT1-MMP/MMP2 pathway.
Liao H, Wang Z, Deng Z, Ren H, Li X.
Int J Clin Exp Med. 2015 Jun 15;8(6):8948-57. eCollection 2015.

24. Perioperative versus Preoperative Chemotherapy with Surgery in Patients with Resectable Squamous Cell Carcinoma of Esophagus: A Phase III Randomized Trial.
Zhao Y, Dai Z, Min W, Sui X, Kang H, Zhang Y, Ren H, Wang XJ.
J Thorac Oncol. 2015 Sep;10(9):1349-1356. doi: 10.1097/JTO.0000000000000612.

25. Let-7a regulates mammosphere formation capacity through Ras/NF-κB and Ras/MAPK/ERK pathway in breast cancer stem cells.
Xu C, Sun X, Qin S, Wang H, Zheng Z, Xu S, Luo G, Liu P, Liu J, Du N, Zhang Y, Liu D, Ren H.
Cell Cycle. 2015;14(11):1686-97. doi: 10.1080/15384101.2015.1030547.

26. DICER1 regulated let-7 expression levels in p53-induced cancer repression requires cyclin D1.
Sun X, Tang SC, Xu C, Wang C, Qin S, Du N, Liu J, Zhang Y, Li X, Luo G, Zhou J, Xu F, Ren H.
J Cell Mol Med. 2015 Jun;19(6):1357-65. doi: 10.1111/jcmm.12522. Epub 2015 Feb 20.

27. Indomethacin induces apoptosis in the EC109 esophageal cancer cell line by releasing second mitochondria-derived activator of caspase and activating caspase-3.
Qin S, Xu C, Li S, Yang C, Sun X, Wang X, Tang SC, Ren H.
Mol Med Rep. 2015 Jun;11(6):4694-700. doi: 10.3892/mmr.2015.3331. Epub 2015 Feb 11.

28. [E-cadherin expression and CDH1 promoter methylation in sporadic and hereditary gastric cancer].
Li XJ, Zhao Y, Ren H.
Nan Fang Yi Ke Da Xue Xue Bao. 2015 Jan;35(1):125-7. Chinese.

29. ARNT2 is downregulated and serves as a potential tumor suppressor gene in non-small cell lung cancer.
Yang B, Yang E, Liao H, Wang Z, Den Z, Ren H.
Tumour Biol. 2015 Mar;36(3):2111-9. doi: 10.1007/s13277-014-2820-1. Epub 2015 Jan 23.

30. Intestinal obstruction due to primary intestinal melanoma in a patient with a history of rectal cancer resectioning: A case report.
Li G, Tang X, He J, Ren H.
Mol Clin Oncol. 2014 Mar;2(2):233-236. Epub 2013 Nov 26.

31. miRNA-205 affects infiltration and metastasis of breast cancer.
Wang Z, Liao H, Deng Z, Yang P, Du N, Zhanng Y, Ren H.
Biochem Biophys Res Commun. 2013 Nov 8;441(1):139-43. doi: 10.1016/j.bbrc.2013.10.025. Epub 2013 Oct 12.

32. Possible carcinogenesis of tumor suppressor let-7.
Sun X, Fan C, Du N, Ren H.
Med Hypotheses. 2013 Sep;81(3):410-3. doi: 10.1016/j.mehy.2013.05.033. Epub 2013 Jun 18.

33. [Expressions of COX-2, PKC-α and miR-101 in gastric cancer and their correlations].
Sun H, Wei Y, Tu H, DU N, Zhao Y, Hu L, Ren H.
Nan Fang Yi Ke Da Xue Xue Bao. 2013 Apr;33(4):559-62. Chinese.

34. Cerebral hernia caused by a thoracic surgery for multiple schwannomas in a patient with Neurofibromatosis type 2.
Qin S, Yang C, Ren H.
Turk Neurosurg. 2013;23(2):245-8. doi: 10.5137/1019-5149.JTN.4091-11.1.

35. Let-7: a regulator of the ERα signaling pathway in human breast tumors and breast cancer stem cells.
Sun X, Qin S, Fan C, Xu C, Du N, Ren H.
Oncol Rep. 2013 May;29(5):2079-87. doi: 10.3892/or.2013.2330. Epub 2013 Mar 6.

36. [E-cadherin expression and CDH1 promoter methylation in sporadic and hereditary gastric cancer].
Li XJ, Zhao Y, Ren H.
Nan Fang Yi Ke Da Xue Xue Bao. 2013 Jan;33(1):125-7. Chinese.

37. Overexpression of Smac promotes Cisplatin-induced apoptosis by activating caspase-3 and caspase-9 in lung cancer A549 cells.
Qin S, Yang C, Wang X, Xu C, Li S, Zhang B, Ren H.
Cancer Biother Radiopharm. 2013 Mar;28(2):177-82. doi: 10.1089/cbr.2012.1261. Epub 2012 Dec 19.

38. Tumor necrosis factor α stimulates Her-2 cleavage by activated caspase-8.
Li X, Zhao Y, Zhang Y, Du N, Ren H.
Cell Physiol Biochem. 2012;30(4):889-97. doi: 10.1159/000341466. Epub 2012 Aug 27.

39. [Role of let-7 in maintaining characteristics of breast cancer stem cells].
Sun X, Fan C, Hu LJ, Du N, Xu CW, Ren H.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Aug;28(8):789-92. Chinese.

40. [Expression of caspase-8 in non-small cell lung cancer and its role in invasion and metastasis of lung cancer A549 cells].
Du N, Sun XF, Hu LJ, Sun X, Li XJ, Zhao Y, Ren H.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Jun;28(6):572-5. Chinese.

41. EMT phenotype is induced by increased Src kinase activity via Src-mediated caspase-8 phosphorylation.
Zhao Y, Li X, Sun X, Zhang Y, Ren H.
Cell Physiol Biochem. 2012;29(3-4):341-52. doi: 10.1159/000338489. Epub 2012 Apr 3.

42. [Overexpression of Smac gene enhanced chemotherapeutic sensitivity of esophageal cancer cell line Eca109 to cisplatin].
Du N, Yang B, Hu LJ, Zhao Y, Sun X, Guo ZW, Ren H.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Apr;28(4):344-6. Chinese.

43. Angiotensin II receptor type 1 blockers suppress the cell proliferation effects of angiotensin II in breast cancer cells by inhibiting AT1R signaling.
Du N, Feng J, Hu LJ, Sun X, Sun HB, Zhao Y, Yang YP, Ren H.
Oncol Rep. 2012 Jun;27(6):1893-903. doi: 10.3892/or.2012.1720. Epub 2012 Mar 13.

44. Smac: Its role in apoptosis induction and use in lung cancer diagnosis and treatment.
Qin S, Yang C, Li S, Xu C, Zhao Y, Ren H.
Cancer Lett. 2012 May 1;318(1):9-13. doi: 10.1016/j.canlet.2011.12.024. Epub 2012 Jan 3. Review.

45. [Construction and expression of eukaryotic expression plasmid pcDNA3.1-smac].
Qin SD, Ren H, Li XJ, Yang CC, Yang B, Zhang XZ, Li SS, Hu LJ.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011 Feb;27(2):146-9. Chinese.

46. From procaspase-8 to caspase-8: revisiting structural functions of caspase-8.
Zhao Y, Sui X, Ren H.
J Cell Physiol. 2010 Nov;225(2):316-20. doi: 10.1002/jcp.22276. Review.

47. [Expression and significance of PCNA and Caspase-3 in the tissue of lung cancer].
Zhao Y, Li XJ, Sui X, Tang XJ, Qin H, Ren H.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2010 Feb;26(2):154-6. Chinese.

48. [Upregulation of survivin in non-small cell lung cancer and its clinicopathological correlation with p53 and Bcl-2].Han PH, Li XJ, Qin H, Yao J, DU N, Ren H.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 Aug;25(8):710-3. Chinese.

49. [Interference of survivin in pancreatic cancer Bx-PC3 cell line with Smac sensitizing its response to cisplatin].
Li XJ, Qin H, Yao J, DU N, Ren H.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 Jun;25(6):522-4. Chinese.

50. Analysis of variabilities of serum proteomic spectra in patients with gastric cancer before and after operation.
Ren H, Du N, Liu G, Hu HT, Tian W, Deng ZP, Shi JS.

World J Gastroenterol. 2006 May 7;12(17):2789-92.

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更新日期:2018-01-11